CRSIRP/Cas gene editing for HIV

What is it about?

CRISPR/Cas has been described as a universal method for editing any gene in any organism. As such, it provides exciting new approaches for the therapy of HIV-1. Here we discuss the various uses of CRISPR/Cas for gene therapy of HIV-1, including some of the more sophisticated ways it could be deployed. As an emerging technology, we provide opinions on the direction we think the technology will go, and some of the limitations and hurdles that we still face.

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Why is it important?

With over 3000 CRISPR/Cas-related publications in the past 12 months, this review provides a timely and succinct survey of the field. They take the technology "out of the box" and think very broadly about the therapeutic landscape for HIV-1. It is written in a manner that is easy to understand, guides the reader to the important references in the literature, and provides a clear basis from which to judge how both the technology could be used, and which hurdles must be cleared before it can gain