What is it about?
In the overview, the concept of spatially distributed redox mediators is considered with particular emphasis to the signal generation and biospecific layer assembling. The application of non-conductive polymers bearing redox labels, supramolecular carriers with attached DNA aptamers and redox active dyes and E-sensor concept are considered as examples of the approach announced.
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Why is it important?
DNA and aptasensors are widely used for fast and reliable detection of disease biomarkers, pharmaceuticals, toxins, metabolites and other species necessary for biomedical diagnostics. The approaches described offer universal platforms for signal generation and quantification of specific interactions like DNA-protein, DNA-DNA and aptamer - low molecular analyte.
Perspectives
The approaches described can be easily extended by variation of biochemical receptors and platforms utilized for spatial pre-organization of reactants on the biosensor interface
Gennady Evtugyn
Kazanskij Privolzskij Federal'nyj Universitet
Read the Original
This page is a summary of: Electrochemical DNA sensors based on spatially distributed redox mediators: challenges and promises, Pure and Applied Chemistry, September 2017, De Gruyter,
DOI: 10.1515/pac-2016-1124.
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