Small peptides with potential cardiovascular regulatory functions from Atlantic salmon skin

What is it about?

Salmon skin collagen peptides (SSCPs) have potential for improving physiological conditions such as early alcoholic liver injury, type 2 diabetes, and hypertension. Here, we focused on the in vitro effects of SSCPs on vascular function. SSCPs were produced by hydrolyzing Atlantic salmon (Salmo salar L.) skin with alcalase and papain and were separated by reverse-phase liquid chromatography. A total of 10 low-molecular-weight peptides were newly identified by mass spectrometry and were applied to an in vitro analysis of cholesterol-reducing, vasorelaxing, and antithrombotic activities. The results showed that the SSCPs contained six cholesterol-lowering peptides (AP, LQ, NVG, RER, PH, and GPR), two vasorelaxant peptides (LQ and PH), and four antithrombotic peptides (GPR, RER, VDGK, and VR) as novel candidate peptides with beneficial effects on vascular function. These active peptides were also quantified in SSCPs. This study reveals that several peptides from salmon skin possess bifunctional properties.

Featured Image

Why is it important?

Salmon skin collagen peptides (SSCPs) contained six cholesterol-lowering peptides (AP, LQ, NVG, RER, PH, and GPR), two vasorelaxant peptides (LQ and PH), and four antithrombotic peptides (GPR, RER, VDGK, and VR) as novel candidate peptides with beneficial effects on vascular function.