What is it about?
Spiro[cyclohexane-1,3’-indoline]-2,2’-diones were easily prepared in good to high yields by the oxidation of N-aryl-N-methyl-2-oxocyclohexane-1-carboxamides in one pot with a short reaction time. The spiroindolinediones could be important for the total synthesis of natural products.
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Why is it important?
A simple and convenient one-pot synthesis of spiro[cyclohexane-1,3’-indoline]-2,2’-diones 2a-j was demonstrated. The spiro compounds would be important for the total synthesis of several natural products as the starting material. The scope of the reaction using the N-aryl-2-oxocycloalkane-1-carboxamides and synthetic applications using the spiro compounds are currently underway.
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This page is a summary of: Facile Synthesis of Spiro[cyclohexane-1,3’-indoline]-2,2’-diones, Heterocyclic Communications, December 2019, De Gruyter,
DOI: 10.1515/hc-2019-0022.
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