Simple oximes of 3′-O-aminothymidine inhibit HIV replication

What is it about?

3'-O-aminothymidine is a nucleoside analogue of special interest as a cleavable primer extension terminator and as a substrate for synthesis of antisense oligonucleotides. We have obtained this analogue by the optimized procedure and additionally characterized all the intermediate products. The final isolated acetoxime of 3'-O-aminothymidine (syn-/anti-isomers mixture) possess anti-HIV activity and prevent cells from syncytia formation caused by HIV-1 infection.

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Why is it important?

Our method of synthesis summarizes previous findings of many research groups and allows to obtain 3'-O-aminothymidine with minimum losses during purification at many stages. At the same time, this type of 3'-O-aminothymidine oxime has not yet been tested for anti-HIV activity among many other 3'-modified nucleoside analogues.