Accurate non-ceruloplasmin bound copper: a new biomarker for the assessment and monitoring of Wilson disease patients using HPLC coupled to ICP-MS/MS

What is it about?

Wilson disease, a rare inherited disease affects the body's ability to handle the essential metal copper. As a result copper accumulates in the tissues, leading to liver and brain injury and death if left undiagnosed. The tests currently used for diagnosis and monitoring are crude, invasive and inaccurate. The current work investigates new biomarkers based on the measurement of the main copper protein in the blood, ceruloplasmin by separation followed by inorganic mass spectrometry. Accurate and relative non-ceruloplamin copper were shown to differentiate between patients with and without the disease and offer an improved approach to treatment monitoring and diagnosis.

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