Improving protocols for α-synuclein seed amplification assays: analysis of preanalytical and analytical variables and identification of candidate parameters for seed quantification

What is it about?

The development of seed amplification assays which could detect misfolded α-synuclein in vivo with high accuracy has been a landmark advancement leading the redefinition of Parkinson’s disease and dementia with Lewy bodies as biological entities rather than as clinical syndromes. We systematically analysed different parameters affecting the assay to improve its reproducibility and potentially allow for quantification which is crucial for clinical use.

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