What is it about?
We have investigated the dynamic thiol-disulphide homeostasis in the RLS patients, using a novel method and assessed correlations between the TDH and disease severity indexes. Our results demonstrated that measurement of dynamic TDH, as an indicator of redox status, is important in the diagnosis and follow-up of the RLS patients.
Featured Image
Why is it important?
Since the formation of disulphide bonds, which have detrimental cellular effects, is reversible, the progression of diseases such as RLS whose etiopathogenesis involves abnormal thiol-disulphide homeostasis can be controlled, even its progression can be prevented. Therefore, thiol-disulphide homeostasis is of increasing interest for researchers and clinicians.
Perspectives
Dynamic TDH was determined by an automatic-spectrophotometric method developed by the co-authors of this manuscript, Erel and Neselioglu. All together with our findings, we recommended to stabilize TDH with dopamine agonists and iron supplementation as well as compounds such as glutathione, precursor N-acetylcysteine and glutamate in RLS patients.
Tomris Ozben
Read the Original
This page is a summary of: Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome, Clinical Chemistry and Laboratory Medicine (CCLM), March 2021, De Gruyter,
DOI: 10.1515/cclm-2020-1659.
You can read the full text:
Contributors
The following have contributed to this page
