Pediatric reference intervals for 1,25-dihydroxyvitamin D using the DiaSorin LIAISON XL assay in the healthy CALIPER cohort

What is it about?

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D), plays a critical role in calcium and phosphate homeostasis. However, no pediatric reference interval (i.e. normal range) currently exists. In this study, we use a new, fully automated assay to measure 1,25(OH)2D in serum samples from healthy children and adolescents to establish age- and sex-specific reference intervals for the pediatric population. Levels of 1,25(OH)2D were found to be higher in neonates and infants compared to older children. These reference intervals should aid in improved clinical assessment of this active form of vitamin D in children and adolescents.

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