What is it about?
This study is about the the effects and regulatory mechanism of fucoidan derived from Undaria pinnatifida on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes. These results conclusively suggested thatfucoidan regulated type II collagen expression via the p38 and AKT pathways, and COX-2 expression via the p38, ERKand AKT pathways in rabbit articular chondrocytes.
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Why is it important?
However, the effects of fucoidanin chondrocytes are not well established. Previously, we have reported in vitro and in vivo anti-inflammatory effects of fucoidan. In this study, we evaluated the effects and regulatory mechanism of fucoidan derived from Undaria pinnatifida on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes.
Perspectives
Moreover, given its ability to mediate cell differentiation and exert anti-inflammatory activity, fucoidan may represent a potential therapeutic substance for use in inflammatory conditions,including arthritis.
Dr. Abdul-Rehman Phull
Shah Abdul Latif University
Read the Original
This page is a summary of: Fucoidan from Undaria pinnatifida regulates type II collagen and COX-2 expression via MAPK and PI3K pathways in rabbit articular chondrocytes, Biologia, November 2017, De Gruyter,
DOI: 10.1515/biolog-2017-0158.
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