Childhood Respiratory Risk Factor Profiles and Middle-Age Lung Function: A Prospective Cohort Study from the First to Sixth Decade

What is it about?

We identify distinct childhood risk profiles, report their different associations with middle-aged lung function and COPD and untangle mediators involved in pathways and effect modifiers. Out, our findings suggest that childhood risk factor profiles are useful to predict long-term lung function and COPD. Our findings can inform potential risk prediction tools to identify those at high risk and interventions to reduce the burden of long-term lung health impairment. Specifically, children with frequent asthma attacks and allergies, especially if they also become adult smokers, are the most vulnerable group that should be targeted for interventions.

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