Morphology of the submandibular gland’s acini of rats in diabetes mellitus

What is it about?

Aim: This study aimed to explore how diabetes affects the salivary glands in rats. Methods: We used male Wistar rats, aged one year, and induced diabetes in them with a single injection. We then examined changes in their salivary glands at three different times: 14 days, 42 days, and 70 days after inducing diabetes. Results: We observed significant changes in the cells of the salivary glands, especially early on. By the 14th day, the cells showed signs of stress and damage. By the 70th day, the cells adapted to the diabetes, showing less damage but signs of shrinkage and normalization in certain cell structures. Conclusion: Our findings suggest that diabetes initially causes severe damage to salivary gland cells, but over time, the cells adapt and show signs of recovery, despite some ongoing shrinkage. This response is typical for cells under stress from high blood sugar levels.

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