What is it about?
This review aims to summarize all programmed and non-programmed cell death (non-PCD) pathways along with their molecular mechanisms, crosstalks and Involvement in the progression of the pathophysiology of SCI to pave the way for developing effective treatment strategies
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Why is it important?
Cell death pathways in spinal cord injury are crucial to understand due to their profound implications for potential therapeutic interventions and patient outcomes. Spinal cord injury often leads to various forms of cell death, including necrosis, apoptosis, and autophagy, which collectively contribute to tissue damage and functional deficits. Elucidating the specific mechanisms and timing of these cell death pathways can inform the development of targeted therapies aimed at minimizing secondary injury and promoting tissue repair. Furthermore, understanding how these pathways intersect with inflammation, oxidative stress, and excitotoxicity in the complex cascade of events following spinal cord injury is essential for devising comprehensive treatment strategies that address multiple facets of the injury process. Ultimately, unraveling the intricacies of cell death pathways in spinal cord injury holds promise for improving the prognosis and quality of life for individuals affected by this devastating condition.
Perspectives
The ensuing cascade of cell death after CNS injury or ischemia has long been considered a target for neuroprotective drugs to preserve tissue and function. Defects in one or more cell death processes are connected to various spinal cord injuries, including neurodegenerative conditions involving abnormal cell destruction. The regulators and signaling pathways of the various cell death mechanisms continue to be appealing therapeutic targets that have the potential to serve as the foundation for translational research that may result in improvements for patients afflicted with these disorders. As a concluding statement, we can say that a significant amount of additional research, including both fundamental works in studies of animal models involving clinical trials, is required to acquire a more in-depth knowledge of the various processes modulating cell death in SCI. Many cell death pathways for axonal/neuronal regeneration and proinflammatory signaling-induced secondary injury in SCI are undiscovered. This review thus expands the extent of the cell death pathways in the SCI, and knowledge must be used
Mr Lahanya Guha
Read the Original
This page is a summary of: Different Ways to Die: Cell Death Pathways and Their Association With Spinal Cord Injury, Neurospine, June 2023, The Korean Spinal Neurosurgery Society (KAMJE),
DOI: 10.14245/ns.2244976.488.
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