What is it about?
Biological Variation Data Critical Appraisal Checklist (BIVAC), which verifies whether publications have included all essential elements that may impact the veracity of associated BV estimates, created by a working Group of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)
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Why is it important?
The BIVAC enables review of studies on BV to critically appraise and classify them with regard to study design, preanalytical handling, analytical methods, and statistical analysis. Our data from a rigorous study of the application of BIVAC to a large volume of published studies indicate that many BV studies omit, or fail to address, essential detail regarding the BIVAC quality Items.
Perspectives
Thus, it provides the potential to drive up quality of future studies and as such may be considered as an initiative that may find an application for BV studies
Anna Carobene
Servizio di Medicina di Laboratorio, Ospedale San Raffaele, Milan, Italy
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This page is a summary of: The Biological Variation Data Critical Appraisal Checklist: A Standard for Evaluating Studies on Biological Variation, Clinical Chemistry, December 2017, AACC,
DOI: 10.1373/clinchem.2017.281808.
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