What is it about?
Detecting viruses, like those that cause pandemics, is crucial for controlling their spread. One common method used for identifying viruses, such as the one that causes COVID-19, is effective but expensive and complicated to use. To address this, researchers developed a new, simpler approach to detect viral RNA, starting with the virus that causes COVID-19. This new method works by recognizing the virus's genetic material and cutting it into pieces using special molecules called ribozymes. Once cut, these pieces trigger a reaction that emits light, making the virus detectable. The method could be used to detect other viruses too, and the researchers even created a low-cost tool to help make it more accessible for use in simple testing environments.
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Why is it important?
The current gold standard for detecting viruses like SARS-CoV-2 in early infection stages comes with high costs and logistical challenges. It requires specialized labor, expensive equipment, and complex transportation and storage solutions, as its components must be refrigerated due to reliance on enzyme activity. In contrast, the proposed method uses molecules that can be transported in a dried form, making logistics simpler and more affordable. The researchers also developed a low-cost tool to further enhance accessibility, particularly for use in basic testing environments. This new method helps overcome many of the logistical barriers of the traditional approach, making it more feasible for countries with large geographic areas and those facing challenges in reaching rural regions.
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This page is a summary of: A novel viral RNA detection method based on the combined use of trans-acting ribozymes and HCR-FRET analyses, PLoS ONE, September 2024, PLOS,
DOI: 10.1371/journal.pone.0310171.
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