Insights from a high-fat diet fed mouse model with a humanized liver

What is it about?

Animal models are vital for investigating the molecular mechanisms contributing to metabolic dysregulation and facilitating novel drug target identification. This paper examines whether chow and purified ingredient control diets induce distinct metabolic responses, and assesses whether a mouse model with human hepatocytes (cDNA-uPA/SCID) can be a useful model of non-alcoholic fatty liver disease upon feeding a high fat diet.

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Photo by Doina Gavrilov on Unsplash

Photo by Doina Gavrilov on Unsplash

Why is it important?

Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disorder worldwide. Some differences exist between mouse and human hepatocyte physiology. Developing a mouse model with human hepatocytes reflects better the physiological response to nutrients.