What is it about?
Phagocytosis activity of monocytes and neutrophils of children with cystic fibrosis shown different behavior between groups with and without chronic rhinosinusitis. The presence of nasal polyps is correlated with a weak activity of this cells in peripheral blood.
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Why is it important?
This could explain that myeloid cells can be also affected by defected chloride-sodium channels defect, not only epithelial cells.
Perspectives
The main efforts connect to innate immune activity need to be improved as a treatment of Cystic fibrosis.
Gustavo Lara Rezende
Universidade de Brasilia
Read the Original
This page is a summary of: Alterations in innate immune responses of patients with chronic rhinosinusitis related to cystic fibrosis, PLoS ONE, May 2022, PLOS,
DOI: 10.1371/journal.pone.0267986.
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