What is it about?
We want to develop a new rapid method of quantitative detection of Covid-19 immunoglobulins. An attempt was made to integrate a newly designed spectrometer into the COVID-19 test strip procedure; this augmentation provides the quantitative capacity for a lateral flow immunoassay (LFIA). Optical interpretation of results by quantitative α index, rather than visual qualification, can be done quickly, in 5–10 minutes. Taking RT-PCR as the diagnostic gold standard, the quantitative spectral LIFA platform could correctly detect all 12 COVID-19 patients. It exhibited the risk of a false-negative diagnosis of RT-PCR in COVID-19 testing. This optical-based platform demonstrated clinical potential.
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Why is it important?
An attempt was made to integrate a newly designed spectrometer into the COVID-19 test strip procedure; this augmentation provides the quantitative capacity for a lateral flow immunoassay (LFIA). Optical interpretation of results by quantitative α index, rather than visual qualification, can be done quickly, in 5–10 minutes.
Perspectives
We demonstrated the ability of an optical-based lateral flow immunoassay platform in the COVID-19 pandemic to capture immunoglobulins early.
Pang-Yen Chen
Mackay Memorial Hospital
Read the Original
This page is a summary of: The early detection of immunoglobulins via optical-based lateral flow immunoassay platform in COVID-19 pandemic, PLoS ONE, July 2021, PLOS,
DOI: 10.1371/journal.pone.0254486.
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