What is it about?
Microglia are immunocompetent cells specifically expressed in the central nervous system. The involvement of microglia in neuropsychiatric disorders such as schizophrenia is suggested well. The activation of such microglia has been shown to be modulated by various factors, one of which is fractalkine. In this paper, we found that various inflammatory stimuli attenuate fractalkine signaling by decreasing the expression of its receptors.
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Why is it important?
With regard to fractalkine, a signal that attenuates the immune response, once stress and psychiatric disorders develop, fractalkine receptors that attenuate the immune response in microglia are reduced, which may result in poor subsequent therapeutic effects.
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This page is a summary of: Modulation of inflammatory responses by fractalkine signaling in microglia, PLoS ONE, May 2021, PLOS,
DOI: 10.1371/journal.pone.0252118.
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