What is it about?
Periodontitis is a pandemic disease. It is a bacteria-driven inflammatory disease that results in the destruction of the supporting tissues of the teeth. About 8-15% of the general population suffers from a severe form of the disease which accounts for up to 5% in ages from 16 to 25 years. The latter group is characterized by rapid progression of the disease.
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Why is it important?
While research of decades found no definite differences in the immunologic and genetic background between rapid and slow progression patients, we suggest that hidden noise in immunologic data might be responsible for the appearance of a rapid progression phenotype. We found hidden noise in lymphocyte counts and neutrophil chemotaxis that compromise the defense system of periodontitis patients. We quantified noise using a special metric that had been designed for that purpose and we were able to discriminate rapid progression from slow progression patients using a simple artificial intelligence model.
Perspectives
By validating the study in other cohorts we will have a strong prognostic tool in dealing with early-onset periodontitis
Dr Georgios Papantonopoulos
University of Patras
Read the Original
This page is a summary of: Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis, PLoS ONE, November 2019, PLOS,
DOI: 10.1371/journal.pone.0224615.
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