The ischemia-reperfunion injury reduced the survival of free flaps

What is it about?

The main objective of this study was to identify the gene expression pattern and histological changes in an I/R injury animal model. Microsurgical anastomoses were objectively assessed using transit-time-ultrasound technology. Seven days after surgery, flap survival was evaluated and tissue samples were harvested for anatomopathological and gene-expression analyses. The Arginase 1 expression level as well as the ratio of Arginase 1/Nitric oxide synthase 2 showed a significant increase in the I/R group.

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Why is it important?

We describe a well-characterized ischemia-reperfusion animal model that may serve to evaluate therapeutic agents under reproducible and controlled conditions. Moreover, this model could be especially useful for the evaluation of arginase inhibitors and different compounds of potential interest in reconstructive microsurgery.