What is it about?
Combination therapy with simvastatin and 5, 6-dimethylxanthenone-4-acetic acid act synergistically on B16.F10 melanoma cells
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Why is it important?
Opens new ways of melanoma therapy.
Perspectives
our data demonstrated that the combined administration of SIM and DMXAA on the co-culture of B16.F10 murine melanoma cells and TAMs under hypoxiamimicking conditions has the potential to become a successful targeted microenvironment therapy, based on the suppression of cancer cell aggressive phenotype.
Professor Elena I Rakosy-Tican
Universitatea Babeş-Bolyai Cluj-Napoca
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This page is a summary of: Combination therapy of simvastatin and 5, 6-dimethylxanthenone-4-acetic acid synergistically suppresses the aggressiveness of B16.F10 melanoma cells, PLoS ONE, August 2018, PLOS,
DOI: 10.1371/journal.pone.0202827.
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