What is it about?
In this work, we search for advantages of knotted topology for protein. In particular, we show, that the knots result in the conformation of the chain creating places favorable for enzymatic active sites. This can justify, why over 80% of knotted proteins are enzymes.
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Why is it important?
This is important in understanding, what is the correlation between structure and function, and possibly in the further development of artificial proteins.
Perspectives
This work shows, how using the chain conformation one can create places favorable for enzymatic active sites. This, on one hand, gives protein-designers new tools in hand, on the other adds a piece to understanding, why knotted proteins were not eliminated by the evolution.
Pawel Dabrowski-Tumanski
University of Warsaw
Read the Original
This page is a summary of: In Search of Functional Advantages of Knots in Proteins, PLoS ONE, November 2016, PLOS,
DOI: 10.1371/journal.pone.0165986.
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