Nervous System-Dependent ISRAA: A Novel Fyn Binding Protein

What is it about?

The article discusses the discovery of a novel immune system modulator called ISRAA. Researchers found that ISRAA plays a role in modulating anti-infection immunity and is involved in a signaling pathway driven by the nervous system. The study provides genomic and structural details of the israa locus, and reveals that ISRAA is a binding partner of Fyn, a member of the Src-family kinases. The research highlights the importance of ISRAA in the regulation of T-cell activation and the phosphorylation of activation tyrosine in mouse splenocytes.

Featured Image

Why is it important?

This research is important because it provides new insights into the interplay between the nervous and immune systems, and the role of the novel immune system modulator ISRAA in this process. Understanding the mechanisms behind this interaction can contribute to the development of new therapies for neurological and immune-related diseases. Key Takeaways: 1. The ISRAA gene is an intron-embedded gene within the zmiz1 gene on chromosome 14, and its transcription is activated in vivo in a manner dependent on intact splenic innervations. 2. The ISRAA protein is likely involved in a signaling pathway driven by the nervous system, and its activation downregulates T-cell activation and the phosphorylation of an activation tyrosine (Y 416 ) of Src-family kinases in mouse splenocytes. 3. ISRAA binds to Fyn, a member of the Src-family kinases, through a typical SH2 binding motif (Y 102 TEV), which facilitates its involvement in protein-protein interactions. Fyn plays a central role in immune system signaling and early T-cell activation signaling by phosphorylating T-cell receptor ITAMs in the CD3 and z chains.