Bio-distribution analysis of intrapericardal administration of mesenchymal stem cells

What is it about?

MSCs viability, proliferative behavior and phenotypic profile were unaffected by exposure to pericardial fluid. In vivo cell tracking by magnetic resonance imaging, histological examination and Y-chromosome amplification clearly demonstrated the presence of MSCs in pericardium, ventricles (left and right) and atrium (left and right) when MSCs were administered into the pericardial space.

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Why is it important?

We demonstrate that pericardial fluid is a suitable vehicle for MSCs and intrapericardial route provide an optimal retention and implantation of MSCs.