PON-P2 for predicting pathogenicity of non-synonymous variations

What is it about?

The article reports a computer tool, PON-P2, for predicting the impact of genetic variations in proteins. All genetic variations in proteins are not harmful. It is difficult to identify which of the several variations are harmful in an individual. PON-P2 helps to detect harmful non-synonymous variations. PON-P2 has better accuracy compared to other similar tools. The main idea of PON-P2 is that 'It is important to classify few variants with high accuracy than to classify all variants with lower accuracy.' PON-P2 calculates reliability of prediction and classifies only the most reliable predictions. So, if a variation is predicted reliably, it is classified as harmful or benign. But if the prediction is not reliable, it is classified as variant of unknown significance.

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Why is it important?

The main idea of PON-P2 is that 'It is important to classify few variants with high accuracy than to classify all variants with lower accuracy.' So, PON-P2 classifies few variants but with high accuracy.