What is it about?
This report presents a strategy of System Biology to select protein targets by integrating interactome and transcriptome data with the purpose of reducing noxious side effects to patients as much as possible. The methodology belongs to a strategy of precision medicine.
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Why is it important?
Noxious side effects of cancer therapies with cytotoxic drugs are deleterious for patient's quality of life and are responsible for 70% of clinical costs.
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This page is a summary of: A Computational Strategy to Select Optimized Protein Targets for Drug Development toward the Control of Cancer Diseases, PLoS ONE, January 2015, PLOS,
DOI: 10.1371/journal.pone.0115054.
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