What is it about?
RT-SHIV-infected macaques were left untreated or treated with suppressive antiretroviral therapy containing an NNRTI. The majority of virally infected cells were located in lymphoid tissues with variable levels in the gastrointestinal tract of both treated and untreated animals. Tissue viral DNA levels correlated with week 1 plasma viremia, suggesting that tissues that harbor proviral DNA are established within the first week of infection. Viral RNA levels were high in lymphoid and gastrointestinal tissues of the untreated animals; animals on ART had little viral RNA expressed in tissues, indicating little or no ongoing viral replication.
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Why is it important?
Strategies for eradication of HIV-1 will need to target residual virus in ART suppressed individuals, which may not be accurately reflected by frequencies of infected cells in blood.
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This page is a summary of: Persistence of Viral Reservoirs in Multiple Tissues after Antiretroviral Therapy Suppression in a Macaque RT-SHIV Model, PLoS ONE, December 2013, PLOS,
DOI: 10.1371/journal.pone.0084275.
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