What is it about?
Multipotent stem cells could substitute damaged cell population and, at the same time, rescue degeneration in neurodegenerative diseases. Here we studied the influence of nanoparticle labelling (already clinically used in patients) on migration of two stem cells populations. We found that labeling significantly impairs movements. Motility impairment was directly proportional to the amount of internalized nanoparticles in cells.
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Why is it important?
In conclusion, this work highlights that SPIOn labeling could affect cell motility in a dose-dependent manner, shedding the light on an important parameter that could be crucial for the creation of novel protocols applicable to clinic. Establishment of an optimal nanoparticle dose, enabling both an excellent visualization of grafted cell by imaging and the maintenance of migration ability, appears fundamental to improve the effects of stem cell therapy.
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This page is a summary of: Dose Dependent Side Effect of Superparamagnetic Iron Oxide Nanoparticle Labeling on Cell Motility in Two Fetal Stem Cell Populations, PLoS ONE, November 2013, PLOS,
DOI: 10.1371/journal.pone.0078435.
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