What is it about?
A genetic approach links terminal reactions of glycolysis to three replication enzymes involved in initiation of DNA replication and lagging strand synthesis during DNA elongation in Bacillus subtilis.
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Why is it important?
Results suggest that properties of three replication enzymes are regulated allosterically upon changes in terminal reactions of glycolysis.
Perspectives
This paper may uncover a universal signaling system allowing modulation of DNA replication with respect to the activity of central carbon metabolism.
Dr Laurent Janniere
Genopole, CNRS, UEVE, Paris-Saclay
Read the Original
This page is a summary of: Genetic Evidence for a Link Between Glycolysis and DNA Replication, PLoS ONE, May 2007, PLOS,
DOI: 10.1371/journal.pone.0000447.
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