Mokola Virus: Geographic Distribution and Genetic Analysis

What is it about?

This study analyzed 18 MOKV isolates from various laboratories over the past 20 years using phylogenetic analysis. The results showed that MOKV isolates from different geographic origins clustered together, indicating a relationship with the Lagos bat virus. The most recent common ancestor of MOKV was estimated to be between 279 and 2034 years old. The study included a comprehensive dataset of MOKV isolates, but some cases were excluded due to uncertainty or lack of available data. The research highlights the importance of tracking virus isolates and understanding the genetic relationships between different MOKV strains.

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Why is it important?

This study is important for several reasons: It provides valuable insights into the phylogeny and diversity of Mokola virus (MOKV), an African lyssavirus species, helping researchers understand its evolutionary history and relationships with other lyssavirus species. By analyzing a comprehensive dataset of MOKV isolates, the study helps identify patterns and relationships between viral isolates based on their geographical origin, providing a better understanding of the virus's distribution and potential risks in different regions. The study highlights the importance of tracking virus isolates, as some reported cases could not be traced due to uncertainty about their existence or lack of available isolates. Key Takeaways: 1. MOKV isolates cluster according to geographic origin, regardless of the genes used for phylogenetic analysis. 2. The most recent common ancestor (MRCA) of MOKV is estimated to be between 279 and 2034 years old, depending on the genes used. 3. Amino acid sites considered influential for viral properties showed a similar pattern across MOKV isolates. 4. The study includes the most comprehensive dataset of MOKV isolates, but some cases could not be traced due to uncertainty or lack of available isolates.