What is it about?
Neuronal connectivity and communication allows fruit flies to visually perceive their environment. We show for the first time that connections between visual motion-detecting neurons have distinct morphologies. These morphologies control the connectivity architectures at the single cell level and between larger sets of visual neurons.
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Why is it important?
Our work shows that connectivity patterns in Drosophila visual neurons surpass the cellular level and reach the single synapse level. This is achieved by polyadic synapses, where one presynaptic site corresponds to multiple postsynaptic densities. By focusing in such synapse morphologies, we unravel important wiring roles of the understudied polyadic morphology in Drosophila.
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This page is a summary of: Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila, PLOS One, October 2025, PLOS,
DOI: 10.1371/journal.pone.0334925.
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