What is it about?
Ketamine, known for its quick effects in treating depression, also comes with some side effects. Our preclinical study took a closer look at two versions of ketamine, S-ketamine and R-ketamine, to understand which is safer for long-term treatment, mirroring the clinical application of ketamine.
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Why is it important?
Our findings show that repeated treatment with S-ketamine led to stronger behavioral changes compared to R-ketamine, suggesting that R-ketamine may be the safer option for long-term use.
Perspectives
Our study contributes additional preclinical evidence indicating that R-ketamine could be a safer option for antidepressant medication when compared to S-ketamine. Clinical trials involving R-ketamine are needed to validate these preclinical results.
Kristian Elersič
Brain Research Lab, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
Read the Original
This page is a summary of: Behavioral sensitization and tolerance induced by repeated treatment with ketamine enantiomers in male Wistar rats, PLoS ONE, March 2024, PLOS,
DOI: 10.1371/journal.pone.0299379.
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