What is it about?
Proliferative Diabetic Retinopathy (PDR) is a chronic complication of Diabetes and the main cause of blindness among the world’s working population at present. We perform an integrated transcriptome bioinformatics analysis based on RNA-sequencing and single-cell RNA sequencing for the first time to identify differentially expressed genes, cellular communications and key ligand-receptor interactions in the fibro (Vascular) membranes (FVMs) cells of PDR patients.
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Why is it important?
This study aims to identify PDR’s biomarkers and potential therapeutic targets by conducting bioinformatics analysis. We identified the upregulation of POSTN, ICAM and CD44 as biomarkers of PDR. Among them, POSTN might act as key ligand by binding with integrin αvβ5 on fibroblasts, leading to the proliferation and migration of fibroblasts and the formation of FMVs. It will provide deeper insight into the comprehensive molecular changes of PDR pathogenesis.
Perspectives
It is hoped that this article will bring new perspectives to the study of the pathogenesis of PDR.
Nan Gao
Tianjin Medical University
Read the Original
This page is a summary of: The integrated transcriptome bioinformatics analysis identifies key genes and cellular components for proliferative diabetic retinopathy, PLoS ONE, November 2022, PLOS,
DOI: 10.1371/journal.pone.0277952.
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