What is it about?
Antibodies are one of the most important kind of drugs and are increasingly used for treatment of all kinds of disease. They are so effective because they can interact with the immune system in many different ways. However, some of these natural mechanisms can result in serious side effects. At present, about 40% of therapeutic antibodies have some sort of modification to reduce the unwanted interactions and side effects, but the present methods only go part of the way. We have now found a way to modify antibodies which completely abolishes the unwanted interactions without affecting all the other desirable properties.
Featured Image
Photo by ANIRUDH on Unsplash
Why is it important?
Our new method of antibody engineering will enable the safe and effective application in many situations - for example in cancer, neurology, autoimmunity. It will be particularly useful in combination with other emerging technologies such as 'bispecific' antibodies and antibody-drug conjugates (i.e. antibodies coupled to other drugs). It has the potential to reduce side effects of treatment, to make new treatments more widely available and to make dosing more convenient.
Perspectives
Read the Original
This page is a summary of: Fc-engineered antibodies with immune effector functions completely abolished, PLoS ONE, December 2021, PLOS,
DOI: 10.1371/journal.pone.0260954.
You can read the full text:
Resources
Contributors
The following have contributed to this page