What is it about?
A simple spectrophotometric method was developed to determine riociguat in bulk and tablet formulation. The present method lies on the oxidation of MBTH by Fe+3 ions in acidic medium to form active coupling species and followed by its coupling with riociguat to form the chromophore having lmax 660 nm.
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Why is it important?
Validated the proposed method as per the existing guidelines of ICH. Good linearity (r~ 0.999) was observed for calibration curve in the studied concentration range (6.25 – 37.50 μg mL-1).
Perspectives
Reproducibility, accuracy and precision of the method were confirmed from low values of % RSD.
Prof Ratnakaram Venkata Nadh
GITAM University
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This page is a summary of: Determination of Riociguat by Oxidative Coupling Using Visible Spectrophotometry, Oriental Journal Of Chemistry, March 2019, Oriental Scientific Publishing Company,
DOI: 10.13005/ojc/35specialissue107.
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