What is it about?
Nitric Oxide (NO) is the most researched and published medical molecule in history. It's medicinal properties are well documented, however its role in skin wound healing across the cellular and molecular skin wound healing sequence is not well understood. This article seeks to identify a continuous mode of action in NO across all phases of wound healing. Specifically, it identifies the localized NO Concentration (NOC) as a continuous function or mode of action across the entire wound healing spectrum and demonstrates that positive modulation of this function can spell the difference between acute wound healing and hard to heal (chronic case) wound healing. Most importantly, it demonstrates that active, exogenous supplementation of the local NOC can place hard to heal wounds on a positive healing vector out of traditional wound chronicity.
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Why is it important?
Chronic or hard to heal skin wounds such as ischemic, pressure, venous, and neuropathic ulcers have become epidemic and often lead to amputations, not to mention the severe sufferings endured by patients even after months or years of exposure to best practice medicine. Understanding nitric oxide's (NO's) role in cellular and molecular skin wound healing and practicing appropriate exogenous NO concentration supplementation will help reverse this trend--often avoiding amputations and further wound debridement, etc.
Perspectives
Researching the roles of nitric oxide (NO) in skin wound healing has been a mind expanding opportunity, especially as its medicinal role in each phase of cellular and molecular skin wound healing has revealed itself. Recognizing the continuous nature of NO concentration (NOC) across this spectrum has elucidated an exciting, yet unexplored and vastly underdeveloped potential for topically supplementation of localized NOC. Equalling exciting, yet immensely challenging is development of a means of applying this unstable (with a half-life of less than 3 seconds when exposed to ambient air) molecular gas to skin wound tissues. It is my hope that recognition of the enormous potential of harnessing NO in skin wound healing will lead to the development of practical, simple NO-based clinical alternatives for re-establishing hard to heal wounds on a positive healing trajectory.
David Bell
NOxy Health Products, Inc.
Read the Original
This page is a summary of: A continuous mode of action of nitric oxide in hard-to-heal wound healing, Journal of Wound Care, December 2024, Mark Allen Group,
DOI: 10.12968/jowc.2024.0004.
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