What is it about?
This publication highlights a common entry route used by several viruses to infect human hosts. Their entry pattern subdues related genetic pathways leading to inhibition of Major Histocompatibility Class I genes.
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Why is it important?
This work brings to light the role of LCK a key gene whose role is critical to viral inhibition but viral pathogens turn to control its splicing machinery rendering it non functional. This will guide new therapeutic decisions addressed by our group
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This page is a summary of: Identification of genetic pathways driving Ebola virus disease in humans and targets for therapeutic intervention, F1000Research, December 2016, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.9778.1.
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