What is it about?
The analysis of S protein from COVID-19 (SARS-CoV-2) revealed that this protein could interact with the actin protein (https://f1000research.com/articles/9-52). This result suggests that compounds which prevent this interaction could have some therapeutic and preventive effect against COVID-19.
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Why is it important?
Food supplements as a possible supportive therapy for COVID-19 disease Study: The analysis of S protein from COVID-19 (SARS-CoV-2) revealed that this protein could interact with the actin protein (https://f1000research.com/articles/9-52). This result suggests that compounds which prevent this interaction could have some therapeutic and preventive effect against COVID-19. Data mining in PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) revealed three natural compounds that directly (quercetin and epigallocatechin gallate) or indirectly (vitamin D) bind the actin protein. These compounds could to some extent suppress infection and dissemination of COVID-19 in the body of infected people. Conclusion: In this phase of the coronavirus pandemic, when specific drugs and vaccines are not available, the food supplements with vitamin D, quercetin and epigallocatechin gallate (the extract of the green tea) could be used as an inexpensive and nontoxic supportive therapy for the COVID-19 disease.
Perspectives
The interaction between S protein from COVID-19 and actin protein should be experimentally confirmed as an important therapeutic target when an appropriate animal system will be available.
Dr Veljko Veljkovic
Institute Vinca
Read the Original
This page is a summary of: Use of the informational spectrum methodology for rapid biological analysis of the novel coronavirus 2019-nCoV: prediction of potential receptor, natural reservoir, tropism and therapeutic/vaccine target, F1000Research, January 2020, Faculty of 1000, Ltd.,
DOI: 10.12688/f1000research.22149.2.
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