BRCA1 novel mutation V1736D and in silico analysis of SNP Q356R in Sudanese patients with breast cancer

What is it about?

The heterozygous status of this variation Q356R has been concluded previously on the both sides; reports were found among negative association studies; nevertheless, the variant heterozygosity still was also found to alter the normal cellular behavior at protein expressional level studies. literature was minimally covered with African reports of such variation and the African nature of this Q356R was poorly investigated in which the entire region was represented by one Moroccan study to conclude more size recommendation by which our study has come out in an agreement with this conclusion; in which, no breast cancer borne within patient’s families together with the early onset disease characteristic found in patients with this variation Q356R in the two studies and the sample size.

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