POSEIDON’s stratification of ‘Low prognosis patients in ART”: The WHY, the WHAT, and the HOW

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The POSEIDON group proposes a change in the definition of POR from heterogeneous criteria to the concept of low prognosis, which may better reflect the fate of these patients in ART. The POSEIDON criteria combine oocyte quality and quantity for the stratification of patients with a confirmed or an expected inappropriate ovarian response, and allow clinicians to estimate the number of oocytes needed to achieve a new marker of success, i.e., at least ONE euploid embryo for transfer in each patient. Using Poseidon, the clinician can classify their patients with a low prognosis in ART properly and estimate the number of oocytes needed to obtain at least one euploid blastocyst for transfer in each patient. Then, the doctor can design an individualized therapeutic plan with the mindset to achieve the target number of oocytes to most optimally manage the patient’s clinical scenario. The new concept of low prognosis helps to improve the management of patients undergoing ART, promotes a tailored approach to patient handling, and identifies more homogeneous populations for clinical trials, thereby providing better tools with which to maximize IVF success rates.

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