What is it about?
shows that FXR and bile acids control PPAR alpha expression and activity and as such fatty acid oxidation in the liver only in humans
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Why is it important?
first time that a cross talk between FXR and bile homeostasis and PPAR alpha and fatty acid oxidation was shown, FXR can re-inforced PPAR alpha agonist activity in liver
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This page is a summary of: Bile Acids Induce the Expression of the Human Peroxisome Proliferator-Activated Receptor α Gene via Activation of the Farnesoid X Receptor, Molecular Endocrinology, February 2003, Endocrine Society,
DOI: 10.1210/me.2002-0120.
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