What is it about?
women with high prolactin have reduced reproductive hormones. We showed in mice that high prolactin inhibits reproductive hormones and especially kisspeptin and that kisspeptin can restore reproductive cycles. We now showed that kisspeptin restores reproductive hormones in patients with pituitary tumours which elevate prolactin.
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Why is it important?
our discovery is important because some women with high prolactin do not respond to prolactin lowering therapeutics and kisspeptin treatment can restore fertility to them.
Perspectives
I am excited about translating lab discoveries into the clinic. Our demonstration of restoring fertility in mice with high prolactin has now been demonstrated in women with high prolactin.
robert millar
University of Pretoria
Read the Original
This page is a summary of: Hypothalamic-Pituitary-Ovarian Axis Reactivation by Kisspeptin-10 in Hyperprolactinemic Women With Chronic Amenorrhea, Journal of the Endocrine Society, October 2017, Endocrine Society,
DOI: 10.1210/js.2017-00328.
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