What is it about?
We found that independent of the overfeeding diet given, there was an intra-individual preference to use carbohydrate (sugar) or fat, meaning that individuals who burned more carbs, did so in all overfeeding diets. We also found that individuals with higher epinephrine concentration during fasting decrease the least in energy expenditure (calorie burn by the body), when compared to energy balance energy expenditure.
Featured Image
Why is it important?
it is important to find markers for individuals at risk of weight gain, and individuals that decrease more their EE during fasting, i.e., thrifty individuals, are at such risk. One mark we found was epinephrine during fasting. Also, it is important for individuals to understand that their body may prefer an specific fuel, and therefore adjust their diet. This maybe an explanation why a specific diet does not uniformly work while someone is trying to lose weight.
Perspectives
With this work, we open a new research opportunity: the need to understand why one's body prefer carbohydrate or fat while overfeeding. This maybe secondary to different hormonal responses, or liver capacity to deposit glycogen, or other unknown factor. Finding those answers, may help us to provide more individualized care for individuals that are trying to lose weight. We also found more differences between the thrifty vs. the spendthrift phenotypes, and further research is needed to further characterization.
Dr. Karyne L Vinales
NIDDK
Read the Original
This page is a summary of: The Consistency in Macronutrient Oxidation and The Role for Epinephrine in the Response to Fasting and Overfeeding., The Journal of Clinical Endocrinology & Metabolism, November 2016, Endocrine Society,
DOI: 10.1210/jc.2016-3006.
You can read the full text:
Contributors
The following have contributed to this page
