What is it about?
TGF-b1 was able stimulated calcium uptake in short term incubations (2 and 20 min). In contrast to the rapid stimulation of 45-Ca2+ uptake previously observed in response to FSH (<1 min), the response to TGF-b1 required several hours and was abolished by actinomycin-D. Although TGF-b1 had no effect on basal calcium uptake before 1 h, it completely inhibited the FSH-stimulated calcium uptake in short term incubations (2 and 20 min).
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Why is it important?
These effects on calcium metabolism may be directly related to the ability of TGF-b1 to regulate cell growth and differentiation.
Perspectives
It should be noted that TGF-b1 also upregulates the expression of the Na+/Ca2+ exchanger (NCX), which extrude Ca2+ from cells. Ref.: Carrillo C, Cafferata EG, Genovese J, O'Reilly M, Roberts AB, Santa-Coloma TA. TGF-beta1 up-regulates the mRNA for the Na+/Ca2+ exchanger in neonatal rat cardiac myocytes. Cell Mol Biol (Noisy-le-grand). 1998 May;44(3):543-51. PubMed PMID: 9620452.
Dr Tomás A. Santa Coloma
Institute for Biomedical Research (BIOMED), CONICET, UCA
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This page is a summary of: Transforming growth factor-beta 1 modulates calcium metabolism in Sertoli cells., Endocrinology, April 1993, Endocrine Society,
DOI: 10.1210/endo.132.4.8462475.
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