Pituitary and Brain Dopamine D2 Receptors Regulate Liver Gene Sexual Dimorphism

What is it about?

A new connection between the pituitary and liver genes is established through the secretion of prolactin and mainly GH. In the present work we demostrate that altered brain or pituitary dopamine function alters this connection and ultimately drastically modifies the expression of liver genes which are distinct in female and males.

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Why is it important?

These results should be born in mind when prescribing antidopaminergic drugs in mental illness; these may modify the expression and therefore activity of liver enzymes, which participate in general metabolism, and in drug pharmacokinetics.