What is it about?
Estrogens are steroids with important physiological actions in humans and indeed in all vertebrates. This paper discusses evidence that estrogens are present in amphioxus, a close ancestor of vertebrates. The evidence is that the response to estrogens first appears in amphioxus.
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Why is it important?
Steroids are important regulators of the physiology of mammals and other vertebrates. This paper builds on other papers showing that estrogens and the receptors that mediate their activities as well as other steroid receptors evolved in amphioxus and lamprey, a basal vertebrate,
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This page is a summary of: Amphioxus, a Primitive Chordate, Is on Steroids: Evidence for Sex Steroids and Steroidogenic Enzymes, Endocrinology, August 2007, Endocrine Society,
DOI: 10.1210/en.2007-0547.
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