What is it about?
Atherosclerotic lesions have areas that are acidic. We and others have been examining how this influences the atherosclerotic lesions. It actually seems that acidic pH increases lipid accumulation in the lesions, increases inflammation, and decreases the good effects of HDL particles. This review article collected all the information in one article.
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Why is it important?
It seems that acidic pH can make atherosclerosis worse. It is important to know the conditions in the lesions and how they influence progression of the disease. The lesions that are particularly acidic may be the ones that cause symptoms - therefore it would be important to know how and why and what can we do to prevent this.
Perspectives
We have been working on the effects of acidity on atherosclerosis for some time - some of these articles are linked below - and wanted to collect all the information from us and others into a review article.
Dr Katariina Öörni
Wihuri Research Institute
Read the Original
This page is a summary of: Acidification of the intimal fluid: the perfect storm for atherogenesis, Journal of Lipid Research, November 2014, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1194/jlr.r050252.
You can read the full text:
Resources
Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.
A research article from our group showing that acidic pH induces inflammasome activation
Spontaneous remodeling of HDL particles at acidic pH enhances their capacity to induce cholesterol efflux from human macrophage foam cells
A research article showing that the functionality of HDL particles decreases at acidic pH
Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH
A research article describing the effect of pH on LDL aggregation
Decrease in pH Strongly Enhances Binding of Native, Proteolyzed, Lipolyzed, and Oxidized Low Density Lipoprotein Particles to Human Aortic Proteoglycans
A research article showing that acidic pH increases retention of native and modified LDL particles by human arterial proteoglycans
Contributors
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