What is it about?
FXR activation leads to a proatherogenic lipoprotein profile by activating CETP which reduces HDL and increased apoB containing lipoproteins
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Why is it important?
These results have clinical relevance, especially when considering FXR agonists as emerging treatment strategy for metabolic disease and atherosclerosis
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This page is a summary of: Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice, Journal of Lipid Research, April 2013, American Society for Biochemistry & Molecular Biology (ASBMB),
DOI: 10.1194/jlr.m038141.
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