What is it about?
This research aims to determine the probable protective effect of nano‑curcumin (N‑CUR) on caffeine (1,3,7‑trimethylxanthine)‑induced neurotoxicity in cerebral rats. Twenty‑four male Wistar rats were divided into three groups: control, caffeine (150 mg kg−1), and caffeine (150 mg kg−1) treated with N‑CUR (300 mg kg−1). All treatments were administrated by gavage every day for a month.
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Why is it important?
Administration of caffeine significantly elevated the levels of serum interleukins 6 (IL‑6), tumor necrosis factor‑alpha (TNF‑α), vascular endothelial growth factor (VEGF), and cyclooxygenase2 (COX‑2). Also, there was a significant increase in levels of cerebral malondialdehyde (MDA), significantly diminished glutathione (GSH), and superoxide dismutase (SOD) activity. Caffeine administration significantly downregulated the gene expression of nuclear factor erythroid 2‑related factor 2 (Nrf2) and upregulated the expression of nuclear factor kappa‑light‑chain enhancer of activated B cells (NF‑κB). Administration of N‑CUR caused a significant amelioration in TNF‑α and IL‑6 levels and a significant rise in SOD activity, while it caused a significant downregulation in NF‑κB mRNA expression. Additionally, N‑CUR has exerted insignificant amelioration of COX‑2 and MDA contents and Nrf2 mRNA expression compared to the cafeine‑treated group. N‑CUR may have a mild to moderate ameliorative effect on caffeine‑induced apoptosis, oxidative stress, and inflammatory response in the cerebrum
Perspectives
These data suggest new findings on the moderate ameliorative effect of N-CUR on cerebral disorders induced by a high dose of caffeine administration. N-CUR diminished cell death, oxidative stress, and inflammation in the cerebrum of caffeine-administered rats as it resulted in a significant improvement in TNF-α and IL-6 levels and a significant elevation in SOD activity; furthermore, it significantly downregulated NF-κB mRNA expression. These data recommend that humans should limit caffeine intake to avoid any adverse problems. Additional investigations into human health should be required
Full Professor Ahmed R. G.
Division of Anatomy and Embryology, Zoology department, Faculty of Science, Beni-Suef University, Egypt.
Read the Original
This page is a summary of: Nano-Curcumin improves caffeine-induced cerebral alterations in male Wistar rats by modifying oxidative stress, inflammation, and COX-2/NF-κB/Nrf2 signaling, Beni-Suef University Journal of Basic and Applied Sciences, September 2024, Springer Science + Business Media,
DOI: 10.1186/s43088-024-00526-5.
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